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报告题目 |
Chiral Brønsted Base Catalyzed Enantioselective Reactions |
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报告时间 |
2011年11月4日上午10：00点 |
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报告地点 |
微尺度国家实验室一楼科技展厅 |
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报告人 |
Professor Choon-Hong Tan |
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报告摘要: We are keen to develop chiral guanidine as general brønsted base catalyst. We found them to be excellent enantioselective catalysts for Michael, Phospha-Michael and Diels-Alder reactions. In this seminar, we would like to present these reaction and two other reactions relating to the enantioselective transfer of protons. In the first reaction, the conjugate addition of arylthiol to 2-phthalimidoacrylate generates a pro-chiral transient enolate which upon protonation gave cysteine analogues with high enantioselectivities. In the second reaction, we showed that guanidine catalyze the 1,3-proton shift reaction, allowing chiral allenes to be prepared directly from alkynes. | |
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报告人简介： Choon-Hong Tan was born in 1971 in Singapore. He received his BSc(Hons) in chemistry from the National University of Singapore（NUS）in 1995. He obtained his PhD from the University of Cambridge in 1999 under the supervision of Prof. Andrew B. Holmes. Following that, he carried out two years postdoctoral work with Prof.Yoshito Kishi at Harvard University. Subsequently, he joined Prof. Robert R.Rando at Harvard Medical School for another year. He joined the Department of Chemistry at NUS as Assistant Professor in 2003. His research interests include asymmetric catalysis, medicinal chemistry and biomaterials. | |
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主办单位：微尺度国家实验室，化学与材料科学学院，研究生院 | |