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报告题目 |
Asymmetric Multidentate Organocatalysis of the aza-Morita-Baylis-Hillman Reaction |
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报告时间 |
2010年12月14日下午4:30 |
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报告地点 |
合肥微尺度物质科学国家实验室一楼科技展厅 |
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报告摘要 |
Counterion-mediated asymmetric catalysis is an effective strategy in organocatalysis or metal-based catalysis. We have initiated an investigation of this strategy in the aza-Morita-Baylis-Hillman (MBH) reaction to address the rate and substrate scope issue. Trifunctional organocatalysts, each containing a Lewis base, a Brønsted base, and a Brønsted acid, have been designed and developed to catalyze this reaction with positive cooperativity. The Brønsted base acts as the switch point to the counterion catalytic pathway, in response to the addition of an external strong Brønsted acid, to furnish fast reaction rates with good enantioselectivity at ambient temperature, with the counteranion of the Brønsted acid additive controlling the sense of the asymmetric induction. Further generations of this new class of organocatalysts have shown improved enantioselective rates and substrate scope in the aza-MBH reaction. Asymmetric multidentate organocatalysis, with positive cooperativity and regulation, may lead to new approaches to enzyme mimicking catalysis with proficiency. |
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报告人 |
Dr. Fei Liu |
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报告人简介 Dr. Fei Liu 是澳大利亚Macquarie University的Senior Lecture. Ramaciotti Research Award, Royal Australian Chemical Institute Athel Beckwith Lectureship, Australian Endeavour Executive Award等获得者。 主要研究方向： 1．Development of catalytic and stereo-selective reactions for efficient generation of useful small molecules as synthetic building blocks or biological probes. 2． Small molecule-based chemical description and understanding of phenotypic variation for studying cancer or antibiotic resistance. 3． Chemistry and biology of post-translational modifications of enzymes or proteomes. 学术成就： 已在J. Am. Chem. Soc.等刊物上发表数十篇高质量学术论文。已经在 | |
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接待单位联系人：王官武 电话：3607864 | |
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合肥微尺度物质科学国家实验室（筹）、化学与材料科学学院、外办（港澳台办） | |